Respirovirus bovis is associated with bovine respiratory disease (BRD)

Respirovirus bovis (Synonym: Bovine parainfluenza virus 3 , BPIV-3) belongs to the family of Paramyxoviridae and has a single-stranded, unsegmented (-)RNA genome . The worldwide distributed BPIV-3 was first isolated in 1959 in the USA from diseased cattle and is associated with the so-called bovine respiratory disease (BRD). This disease is characterized by a non-specific clinical picture, which may include fever, cough, watery eyes, nasal discharge, fatigue, and shortness of breath. BRD often has a mild course, but severe or fatal cases associated with pneumonia have also been described. Outbreaks of BRD in livestock herds are often associated with negative environmental influences, such as stress from animal transport or poor animal husbandry. Within the herds, the transmission of BPIV-3 mainly via aerosols or contact with the nasal secretions of infected animals. To prevent BRD in Germany, several vaccines approved against BPIV-3.

The Host area The BPIV-3 virus strain includes cattle and other domesticated hoofed animals such as sheep, goats, water buffalo, and yaks. BPIV-3 infection of wild hoofed animals (e.g., bison, elk, rhinos, and camels) is also being discussed. To date, only one case of BPIV-3 infection in humans has been described, in a small child with pneumonia. However, clinical studies with attenuated BPIV-3 have shown that humans can, in principle, be infected with BPIV-3 (with low efficiency). In the Technical Rules for Biological Agents (TRBA) 462 "Classification of viruses into risk groups," BPIV-3 is assigned to risk group 1 with the addition " Containment Tier t2^1 ."

The ZKBS classifies Respirovirus bovis according to Section 5 Paragraph 1 GenTSV in conjunction with the criteria in Annex 1 GenTSV as a donor and recipient organism for genetic engineering work in the Risk group 2 The virus has a broad host range; infection in various ungulates and humans is likely associated with respiratory disease.

The ZKBS statement can be found at File number 45242.0212 can be retrieved.